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KMID : 1234520160110010017
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Korean Journal of Urogenital Tract Infection Inflammation
2016 Volume.11 No. 1 p.17 ~ p.24
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Infectious Complications after Prostate Biopsy: A Prospective Multicenter Prostate Biopsy Study
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Hwang Eu-Chang
Yu Ho-Song
Jung Seung-Il
Kwon Dong-Deuk
Lee Sun-Ju
Kim Tae-Hyoung
Chang In-Ho
Yoon Ha-Na
Shim Bong-Suk
Kim Kwang-Hyun
Lee Dong-Hyun
Huh Jung-Sik
Lim Dong-Hoon
Jo Won-Jin
Min Seung-Ki
Lee Gil-Ho
Kim Tae-Hwan
Lee Seo-Yeon
Yang Seung-Ok
Chung Jae-Min
Lee Sang-Don
Han Chang-Hee
Bae Sang-Rak
Choe Hyun-Sop
Lee Seung-Ju
Chung Hong
Na Yong-Gil
Yang Seung-Woo
Kim Young-Ho
Kim Tae-Hyo
Cho Won-Yeol
Han June-Hyun
Cho Yong-Hyun
Ha U-Syn
Park Heung-Jae
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Abstract
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Purpose: Recent studies have highlighted an increasing trend of infectious complications due to fluoroquinolone-resistant organisms among men undergoing transrectal prostate biopsy. This study evaluated the current incidence of infective complications after trans-rectal prostate biopsy for identification of risk factors in Korean men who received fluoroquinolone prophylaxis.
Materials and Methods: A prospective, multicenter study was conducted in Korea from January to December 2015. Prostate biopsies performed with fluoroquinolone prophylaxis during 3 months in each center were included. A pre-biopsy questionnaire was used for identification of patient characteristics. Clinical variables including underlying disease, antibiotic prophylaxis, enema, povidoneiodine cleansing of the rectum, and infectious complications were evaluated. The primary outcome was the post-biopsy infection rate after fluoroquinolone prophylaxis. Univariable and multivariable analyses were used for identification of risk factors for infectious complications.
Results: The study included 827 patients, of whom 93 patients (11.2%) reported receiving antibiotics in the previous 6 months and 2.5% had a history of prostatitis. The infectious complication rate was 2.2%. Post-biopsy sepsis was reported in 2 patients (0.2%). In multivariable analysis predictors of post-biopsy sepsis included person performing biopsy (adjusted odds ratio [OR], 4.05; 95% confidence interval [CI], 1.31-12.5; p=0.015) and operation history within 6 months (adjusted OR, 5.65; 95% CI, 1.74-18.2; p=0.004).
Conclusions: The post-prostate biopsy infectious complication rate in this study was 2.2%. Person performing biopsy (non-urologists) and recent operation history were independent risk factors for infectious complications after trans-rectal prostate biopsy.
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KEYWORD
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Biopsy, Escherichia coli, Fluoroquinolones, Infection, Prostate
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